10.0 does not but we are working to upgrade the code to support Vista, 64 bit processors and be multithreaded. We'll see if the developers can take that one step further to be hyperthreaded. Look for the start of these improvements in early 08 with 10.2.
The current version of eSignal does not take advanage of HyperThreading, however this is very high on our developers priorities list for a future release some time next year.
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